33419

Basic Info.

Model NO.	33419-42-0
Standard	USP/Ep/Bp/Cp/IP/Jp/Who/in-House
Capacity	1000kg/Mon
Transport Package	25kg/Drum/1000g/Bag/10g/Bag
Specification	100% raw material
Trademark	Widely
Origin	China
Production Capacity	1000kg/Mon

Product Description

Contraindications	1. Patients of significantly lower amount of white blood cells and platelets should be disabled.2. Patients of heart, liver and kidney dysfunction should be disabled.3. Pregnant women and lactating women should be disabled.4. Patients allergic to this drug should be disabled.
Uses	It is used as anti-cancer drug mainly used for the treatment of small cell lung cancer, testicular cancer, malignant lymphoma and acute leukemia. It also has certain efficacy in treating neuroblastoma, rhabdomyosarcoma, ovarian cancer, non-small cell lung cancer, stomach cancer and breast cancer.
Usage and Dosage	1. Oral: single-administration; daily: 60~100mg /m2; continuously apply for 10 days and repeat every 3 to 4 weeks. For combination chemotherapy, apply 50 mg/m2 per day and continue to take 3 or 5 days.2. Intravenous infusion: Use sodium chloride injection for dilute this product of required amount (this drug is instable in 5% glucose injection and can form a fine precipitate). The concentration should not be more than 0.25 mg/ml with the intravenous infusion time being not less than 30 minutes.Solid tumors: 60~100mg/m2 per day; continue for 3 to 5 days with repeating the medication every 3 to 4 weeks.Leukemia: 60~100mg/m2 per day; apply for 5 consecutive days; repeat the medication at certain interval according to the blood condition.Common pediatric dose: for intravenous infusion, administer based on volume/surface area 100~150mg/m2 for continuous 3 to 4 days.
Precautions	1. This product is not suitable for intravenous injection and the intravenous infusion rate should not be too fast and should at least last for half an hour, otherwise it can easily lead to hypotension, laryngeal spasm and other allergic reactions.2. Don't choose chest, abdomen and intrathecal injection for administration.3. During the medication period, the patients should be subject be regular investigation on the peripheral blood condition as well as liver and kidney function.4. This product should be administrated immediately after dilution. If precipitate occurs, it should be strictly prohibited.5. This product can cause reproductive toxicity and teratogenicity to animals and can be excreted through breast milk. FDA provided the pregnancy safety of this drug being classified as D class.This information is edited by Xiongfeng Dai from Chemicalbook.
Drug Interactions	1. Because this product has significant bone marrow suppression effect and should be taken care of when be used in combination with other anticancer drugs.2. This product can inhibit the body's immune defense mechanism, so that vaccination is not able to stimulate the body to produce antibodies.3. Within 3 months after the end of chemotherapy, it is not recommended for applying the vaccine virus.4. This product has a high binding rate to the plasma protein and therefore, the drug bound to plasma protein can affect the excretion of this product.
Description	Etoposide is a plant alkaloid and an inhibitor of topoisomerase II (IC50 = 60.3 μM). It inhibits proliferation of a variety of adenocarcinoma cells (IC50s = 0.005-12,200 μM) and human umbilical vein endothelial (HUVEC) cells (IC50 = 0.249 μM). It reduces tumor growth in an Ma human embryonal carcinoma mouse xenograft model when administered at a dose of 25 mg/kg, an effect that is enhanced by concomitant administration of the immunosuppressant cyclosporin A (Item No. 12088). Etoposide also inhibits nuclear receptor coactivator 3 (IC50 = 2.48 μM). Formulations containing etoposide have been used in combination therapy in the treatment of cancer.

Hubei weideli Chemical Reagent Co., Ltd., located in Wuhan East Lake New Technology Development Zone, is a manufacturing supplier focusing on reagent products for scientific research, and its business scope includes the manufacturing of special chemical products; Disinfectant production; Sales of special chemical products; Disinfectant sales; Research and development of biological feed; Research and development of bio based materials technology; Research and development of biochemical products technology; Technical services, technical development, technical consultation, technical exchange, technology transfer and technology promotion; Sales of instruments and meters; Sales of daily glass products; Sales of technical glass products; Sales of electronic special materials; Technology import and export; Import and export of goods; Veterinary drug management; Production of disinfection products for the prevention and treatment of infectious diseases.The company has gradually established extensive cooperation with scientific research institutions in Colleges and universities and powerful enterprises to lay a solid foundation for technological production; At the same time, we will recruit talents all over the country and keep them fresh and energetic; With more than ten years of experience and accumulation in the industry, the company further improves its market competitiveness and strengthens its support to customers.With the help of modern ERP system, the company provides customers with accurate quotation and inventory information in time. It has a warehouse base and Laboratory of more than 1000 square meters in Jiangxia District, Wuhan. The system inventory products can be ordered on the same day, and the order number is given on the same day of delivery. The information can be queried online, followed up in real time, and customer service provides after-sales support services.Hubei weideli Chemical Reagent Co., Ltd. is committed to scientific research.

I. Do you always have this products in stock?Our company has more than 1000 kinds of products in stock. We usually have them in stock. We can show you the information, forms or pictures of our warehouse at any time. If the stock is insufficient, our company will replenish them as soon as possible according to the ERP system.2. What certificates and documents do you offer?According to the situation of products, we can provide COA, NMR, LC, MS, synthesis process, MQA, MSDS, etc3. Why should I choose you?Stock in stock and deliver in timeReasonable priceProduct technology and data supportProfessional sales teamPerfect pre-sale and after-sale service4. Can I get best price from you?We don* t pursue expensive profitsWe always try to give best offerYou can also enjoy fun of bargaining5. How should I pay?T/T bank transfer West union PayPal